[CAS NO. 1425803-45-7] Cyclooctyne-O-NHSester

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PRODUCTS SPECIFICATIONS [1425803-45-7]

Catalog

HY-126517

Brand

MCE

CAS

1425803-45-7

For research use only. We do not sell to patients.

Cyclooctyne-O-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) ^[1] .

Cleavable

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Solid

Room temperature in continental US; may vary elsewhere.

-20°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

In Vitro:

DMSO : 100 mg/mL ( 358.05 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 6.25 mg/mL (22.38 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 5 mg/mL (17.90 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 5 mg/mL (17.90 mM); Clear solution

* All of the co-solvents are available by MCE.