[CAS NO. 157604-55-2] (S)-SNAP5114

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PRODUCTS SPECIFICATIONS [157604-55-2]

Catalog

HY-103504

Brand

MCE

CAS

157604-55-2

DESCRIPTION [157604-55-2]

Overview

MDL	-
Molecular Weight	505.60
Molecular Formula	C30H35NO6
SMILES	O=C([C@@H]1CN(CCOC(C2=CC=C(OC)C=C2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)CCC1)O

For research use only. We do not sell to patients.

Summary

(S)-SNAP5114 is a selective GABA transport inhibitor, with IC ₅₀ values of 5 μM and 21 μM for hGAT-3 and rGAT-2, respectively. (S)-SNAP5114 is an anticonvulsant drug ^[1] ^[2] .

IC50 & Target

IC50: 5 μM (hGAT-3), 21 μM (rGAT-2) ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 197.78 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9778 mL	9.8892 mL	19.7785 mL
5 mM	0.3956 mL	1.9778 mL	3.9557 mL
10 mM	0.1978 mL	0.9889 mL	1.9778 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (4.94 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (4.94 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (4.94 mM); Clear solution

* All of the co-solvents are available by MCE.