[CAS NO. 1010396-29-8] S-23
PRODUCTS SPECIFICATIONS [1010396-29-8]
DESCRIPTION [1010396-29-8]
Overview
| MDL | MFCD24849232 |
|---|---|
| Molecular Weight | 416.75 |
| Molecular Formula | C18H13ClF4N2O3 |
| SMILES | O=C(NC1=CC=C(C#N)C(C(F)(F)F)=C1)[C@@](C)(O)COC2=CC=C(Cl)C(F)=C2 |
1 Publications Citing Use of MCE
Summary
S-23 is an orally active selective androgen receptor modulator (SARM) with a K i of 1.7 nM. S-23 induces androgen receptor (AR)-mediated transcriptional activation in CV-1 cells. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats [1] [2] .
IC50 & Target
Ki: 1.7 nM (Androgen receptor) [1]
In Vitro
S-23 induces AR-mediated transcriptional activation in CV-1 cells when used at a concentration of 10 nM [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
By administration of S-23 to castrated animals, androgen-dependent organ weights increased in a dose-dependent manner. The ED 50 of S-23 in the prostate and levator ani muscle is 0.43 and 0.079 mg/d, respectively [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Male Sprague Dawley rats (in castrated male rats) [1] |
| Dosage: | 0.01-3 mg |
| Administration: | S.c.; daily for 14 d |
| Result: | Androgen-dependent organ weights increased in a dose-dependent manner. At a dose rate as low as 0.1 mg/d, S-23 is able to selectively maintain the weight of the levator ani muscle at the intact control level, whereas its effects on the prostate and seminal vesicles are lower than 30% of those observed in intact controls. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 239.95 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.3995 mL | 11.9976 mL | 23.9952 mL |
| 5 mM | 0.4799 mL | 2.3995 mL | 4.7990 mL |
| 10 mM | 0.2400 mL | 1.1998 mL | 2.3995 mL |
References
- [1] Jones A, et al. Preclinical characterization of a (S)-N-(4-cyano-3-trifluoromethyl-phenyl)-3-(3-fluoro, 4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide: a selective androgen receptor modulator for hormonal male contraception. Endocrinology. 2009;150(1):38
- [2] Thevis M, et al. Characterization of in vitro generated metabolites of the selective androgen receptor modulators S-22 and S-23 and in vivo comparison to post-administration canine urine specimens. Drug Test Anal. 2010;2(11-12):589-598.
Synonyms
