[CAS NO. 1013937-63-7] VTP-27999TFA
PRODUCTS SPECIFICATIONS [1013937-63-7]
DESCRIPTION [1013937-63-7]
Overview
| MDL | MFCD20278230 |
|---|---|
| Molecular Weight | 639.10 |
| Molecular Formula | C28H42ClF3N4O7 |
| SMILES | O=C(O)C(F)(F)F.COC(NCCO[C@@H](C1=CC(Cl)=CC=C1)[C@@]2([H])CN(CCC2)C(NC[C@@H](NC)C[C@H]3CCCOC3)=O)=O |
Summary
VTP-27999 TFA is an alkyl amine Renin inhibitor ; VTP-27999 TFA is useful for Hypertension and End-Organ Diseases.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT01217736 | Vitae Pharmaceuticals, Inc.|Brigham and Women´s Hospital |
Renal Function
|
September 2010 | Phase 1 |
Appearance
Oil
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H 2 O : 10 mg/mL ( 15.65 mM ; Need ultrasonic)
Ethanol : 2.4 mg/mL ( 3.76 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.5647 mL | 7.8235 mL | 15.6470 mL |
| 5 mM | 0.3129 mL | 1.5647 mL | 3.1294 mL |
| 10 mM | 0.1565 mL | 0.7824 mL | 1.5647 mL |
-
1.
Add each solvent one by one: PBS
Solubility: ≥ 25 mg/mL (39.12 mM); Clear solution
References
- [1] New renin inhibitor VTP-27999 alters renin immunoreactivity and does not unfold prorenin. Hypertension. 2013 May;61(5):1075-1082.
- [2] Lanqi Jia? et al. Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility ACS Med. Chem. Lett., 2011, 2 (10), pp 747-751
- [3] Ishchenko A, et al. Structure-based design technology contour and its application to the design of Renin inhibitors.J Chem Inf Model. 2012 Aug 27;52(8):2089-97. Epub 2012 Jul 25.
