[CAS NO. 101526-62-9] Sematilide hydrochloride

Name: Sematilide hydrochloride
Brand: Arctom Scientific
SKU: AS936358

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PRODUCTS SPECIFICATIONS [101526-62-9]

Distributor

Catalog

AS936358

Brand

Arctom Scientific

CAS

101526-62-9

DESCRIPTION [101526-62-9]

Overview

MDL	-
Molecular Weight	349.88
Molecular Formula	C14H24ClN3O3S
SMILES	O=C(NCCN(CC)CC)C1=CC=C(NS(=O)(C)=O)C=C1.Cl

For research use only. We do not sell to patients.

Summary

Sematilide hydrochloride (CK-1752 hydrochloride) is a selective I _Kr channel blocker. Sematilide causes a concentration-dependent inhibition of the delayed rectifier K ⁺ current ( IC ₅₀ =25 μM). Sematilide is a class III antiarrhythmic agent ^[1] .

IC50 & Target

IC50: 25 μM (K ⁺ current) ^[1]

In Vitro

Application of 10, 30, 100 and 300 μM Sematilide causes a concentration-dependent inhibition of the delayed rectifier K ⁺ current (IC ₅₀ =25 μM) ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Sematilide (0.3-1.0 mg/kg, intravenously i.v.) is effective in a canine model of arrhythmia ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mongrel dogs of either sex (10-18 kg body weight) ^[2]
Dosage:	0.3, 1, 3, and 10 mg/kg
Administration:	I.v. infusions
Result:	Demonstrated antiarrhythmic effects at 0.3 and 3.0 mg/kg.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H ₂ O : 50 mg/mL ( 142.91 mM ; Need ultrasonic)

DMSO : 5 mg/mL ( 14.29 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8581 mL	14.2906 mL	28.5812 mL
5 mM	0.5716 mL	2.8581 mL	5.7162 mL
10 mM	0.2858 mL	1.4291 mL	2.8581 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 0.5 mg/mL (1.43 mM); Clear solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 0.5 mg/mL (1.43 mM); Clear solution; Need ultrasonic
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: 0.5 mg/mL (1.43 mM); Clear solution; Need ultrasonic

* All of the co-solvents are available by MCE.