[CAS NO. 101973-77-7] Esonarimod
PRODUCTS SPECIFICATIONS [101973-77-7]
DESCRIPTION [101973-77-7]
Overview
| MDL | MFCD00872973 |
|---|---|
| Molecular Weight | 280.34 |
| Molecular Formula | C14H16O4S |
| SMILES | CC1=CC=C(C(CC(CSC(C)=O)C(O)=O)=O)C=C1 |
Summary
Esonarimod (KE-298) is an antirheumatic agent.
In Vitro
Esonarimod (KE-298) (10 to 300 μg/mL) suppresses the production of NO by RAW264.7 cells in a dose dependent manner. The IC 50 of Esonarimod is 117.5 μg/mL. Esonarimod does not affect cellular viability at these tested doses. Esonarimod has no direct effect on NOS activity in cell-free extracts of RAW264.7 cells [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
After repeated oral administration of Esonarimod ( 14 C-KE-298), the radioactivity decreases rapidly and no tendency towards accumulation is found [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 356.71 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.5671 mL | 17.8355 mL | 35.6710 mL |
| 5 mM | 0.7134 mL | 3.5671 mL | 7.1342 mL |
| 10 mM | 0.3567 mL | 1.7835 mL | 3.5671 mL |
References
- [1] Inoue T, et al. KE-298 and its active metabolite KE-758 suppress nitric oxide production by murine macrophage cells and peritoneal cells from rats with adjuvant induced arthritis. J Rheumatol. 2001 Jun;28(6):1229-37.
- [2] Hasegawa M, et al. Formation of a disulfide protein conjugate of the SH-group-containing metabolite (M-I) ofesonarimod (KE-298) and its elimination in rats. J Pharm Pharmacol. 2002 Apr;54(4):493-8.
Synonyms
