[CAS NO. 1021950-26-4] Tyrosine kinase inhibitor

Name: Tyrosine kinase inhibitor
Brand: Arctom Scientific
SKU: AS906306

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PRODUCTS SPECIFICATIONS [1021950-26-4]

Distributor

Catalog

AS906306

Brand

Arctom Scientific

CAS

1021950-26-4

DESCRIPTION [1021950-26-4]

Overview

MDL	-
Molecular Weight	586.61
Molecular Formula	C31H31FN6O5
SMILES	O=C(NC1=CC=C(C=C1)F)C2(CC2)C(NC3=CC=C(C=C3)OC4=C5C(NC(C(NCCN6CCOCC6)=O)=C5)=NC=C4)=O

For research use only. We do not sell to patients.

Summary

Tyrosine kinase inhibitor is a potent tyrosine kinase inhibitor.

In Vitro

Tyrosine kinases are important mediators of the signaling cascade, determining key roles in diverse biological processes like growth, differentiation, metabolism and apoptosis in response to external and internal stimuli ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 46 mg/mL ( 78.42 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7047 mL	8.5236 mL	17.0471 mL
5 mM	0.3409 mL	1.7047 mL	3.4094 mL
10 mM	0.1705 mL	0.8524 mL	1.7047 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (4.26 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (4.26 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (4.26 mM); Clear solution

* All of the co-solvents are available by MCE.