[CAS NO. 10299-44-2]  8-Azaadenosine

8-Azaadenosine targets ADAR (adenosine deaminases acting on double-stranded RNA) activity only and does not affect ADAR1 mRNA levels ^{[1] [2]} .
8-Azaadenosine (10-25 nM) restores let-7 miRNA biogenesis commensurate with a reduction in ADAR1 expression, RNA editing activity and LIN28B expression in JAK2/BCR-ABL1 transduced progenitors after two weeks in stromal co-culture ^[1] .
8-Azaadenosine (10, 100 nM) shows no effect on BCR-ABL and JAK2 signaling, as demonstrated by qRT-PCR analysis and p-CRKL and p-STAT5a Western blot analysis ^[1] .
8-Azaadenosine (0.1, 0.5, 1, 2 µM; 5 days) decreases cell viability/proliferation in a dose-dependent manner in TPC1 and Cal62 cells ^[2] .
8-Azaadenosine (1, 2 µM; 16 hours) impedes invasion and migration of TPC1 and Cal62 cells ^[2] .
8-Azaadenosine (1, 2 µM) inhibits the editing activity in TPC1 and Cal62 cells. By contrast, ADAR1 mRNA levels remains stable in both cells lines ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.