[CAS NO. 1035094-83-7] Rho-Kinase-IN-1

Name: Rho-Kinase-IN-1
Brand: Arctom Scientific
SKU: AS947620

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PRODUCTS SPECIFICATIONS [1035094-83-7]

Distributor

Catalog

AS947620

Brand

Arctom Scientific

CAS

1035094-83-7

DESCRIPTION [1035094-83-7]

Overview

MDL	MFCD18633216
Molecular Weight	352.50
Molecular Formula	C20H24N4S
SMILES	CSC1=CC=C(CN2CC(NC3=CC4=C(NN=C4)C=C3)CCC2)C=C1

For research use only. We do not sell to patients.

Summary

Rho-Kinase-IN-1 is a Rho kinase (ROCK) inhibitor ( K _i values of 30.5 and 3.9 nM for ROCK1 and ROCK2 , respectively) extracted from US20090325960A1, compound 1.008 ^[1] .

IC50 & Target

ROCK1

30.5 nM (Ki)

ROCK2

3.9 nM (Ki)

In Vitro

Rho-Kinase-IN-1 is a ROCK inhibitor which can be useful for treating diseases or conditions associated with excessive cell proliferation, remodeling, edema and inflammation ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 141.84 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8369 mL	14.1844 mL	28.3688 mL
5 mM	0.5674 mL	2.8369 mL	5.6738 mL
10 mM	0.2837 mL	1.4184 mL	2.8369 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (5.90 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (5.90 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (5.90 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Fulcher, Emilee H, et al. Method for the treatment and prevention of the inflammatory diseases using Rho kinase inhibiting compounds. US 20090325960 A1.