[CAS NO. 104632-25-9] Pramipexole dihydrochloride

Name: Pramipexole dihydrochloride
Brand: Arctom Scientific
SKU: AS065719

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PRODUCTS SPECIFICATIONS [104632-25-9]

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Catalog

AS065719

Brand

Arctom Scientific

CAS

104632-25-9

DESCRIPTION [104632-25-9]

Overview

MDL	MFCD00876894
Molecular Weight	284.25
Molecular Formula	C10H17N3S.2HCl
SMILES	NC1=NC2=C(C[C@@H](NCCC)CC2)S1.Cl

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.5180 mL	17.5901 mL	35.1803 mL
5 mM	0.7036 mL	3.5180 mL	7.0361 mL
10 mM	0.3518 mL	1.7590 mL	3.5180 mL
50 mM	0.0704 mL	0.3518 mL	0.7036 mL

Description

Pramipexole dihydrochloride (SND919) is a agonist of the non-ergoline class indicated for treating Parkinson's disease (PD) and restless legs syndrome (RLS) with Ki values of 3.9 nM, 2.2 nM, 0.5 nM and 5.1 nM for D2S receptor, D2L receptor, D3 receptor and D4 receptor.

Targets

D3 receptor ^[1] (Cell-free)	D2L Receptor ^[1] (Cell-free)	D2S Receptor ^[1] (Cell-free)	D4 receptor ^[1] (Cell-free)
0.5 nM(Ki)	2.2 nM(Ki)	3.9 nM(Ki)	5.1 nM(Ki)

In vivo

In mice, pramipexole (0.001-1 mg/kg s.c.) reduced exploratory locomotor activity. In rats with unilateral striatal lesions, only weak ipsilateral rotation was produced by pramipexole at the highest dose. However, in rats with unilateral lesions of the medial forebrain bundle, pramipexole potently induced contralateral circling (ED50 0.026 mg/kg s.c). In the N-mcthyl-4-phenyl-l,2,3,6 tetrahydropyridine (MPTP) monkey model, pramipexole also had potent stimulatory effects. Pramipexole is, at least in part, transported across the BBB by an organic cation-sensitive transporter. The pramipexole transport is pH-dependent, but sodium- and membrane potential-independent.

References

[1] Kvernmo T, et al. Clin Ther. 2006, 28(8):1065-1078.
[2] Mierau J, et al. Eur J Pharmacol. 1992, 215(2-3):161-70.
[3] Takashi Okura, et al. Life science. 2007, 80(17):1564-1571.

Synonyms

2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N⁶-propyl-, hydrochloride (1:2), (6S)-

2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N⁶-propyl-, dihydrochloride, (S)-

2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N⁶-propyl-, dihydrochloride, (6S)-

Pramipexole dihydrochloride

SND 19

Pramipexole hydrochloride