[CAS NO. 1063331-94-1] NS13001

Name: NS13001
Brand: Arctom Scientific
SKU: AS663809

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PRODUCTS SPECIFICATIONS [1063331-94-1]

Fulfillment

Catalog

AS663809

Brand

Arctom Scientific

CAS

1063331-94-1

DESCRIPTION [1063331-94-1]

Overview

MDL	MFCD26097265
Molecular Weight	353.81
Molecular Formula	C17H16ClN7
SMILES	CN1C=NC2=C(NC3=CC=C(Cl)C=C3)N=C(N4N=C(C)C=C4C)N=C12

For research use only. We do not sell to patients.

Summary

NS13001 is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels). The EC ₅₀ s are 1.8 and 0.14 μM for SK2 and SK3, respectively. NS13001 holds promise as a potential therapeutic agent for treatment of spinocerebellar ataxia type 2 (SCA2) and possibly other cerebellar ataxias ^[1] .

IC50 & Target

EC50: 1.8 μM (SK2), 0.14 μM (SK3) ^[1]

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 282.64 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8264 mL	14.1319 mL	28.2638 mL
5 mM	0.5653 mL	2.8264 mL	5.6528 mL
10 mM	0.2826 mL	1.4132 mL	2.8264 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 0.83 mg/mL (2.35 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 0.83 mg/mL (2.35 mM); Suspended solution; Need ultrasonic
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 0.83 mg/mL (2.35 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Kasumu AW, et al. Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2. Chem Biol. 2012 Oct 26;19(10):1340-53.