[CAS NO. 1072145-33-5] ERRαantagonist-1
PRODUCTS SPECIFICATIONS [1072145-33-5]
DESCRIPTION [1072145-33-5]
Overview
| MDL | MFCD17676143 |
|---|---|
| Molecular Weight | 377.53 |
| Molecular Formula | C21H19N3S2 |
| SMILES | C12=CC=CC=C1C(/N=C3SCCN\3C4=NCCS4)C5=CC=CC=C5C=C2 |
Summary
ERRα antagonist-1 (Compound A) is a selective and high affinity estrogen-related receptor α (ERRα) antagonist. ERRα antagonist-1 inhibits interaction of ERRα with Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β, the IC 50 values are 170 nM and 180 nM, respectively. ERRα antagonist-1 does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα or ERβ with PGC-1α or SRC-1 [1] .
IC50 & Target
|
ERRα |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 25 mg/mL ( 66.22 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.6488 mL | 13.2440 mL | 26.4880 mL |
| 5 mM | 0.5298 mL | 2.6488 mL | 5.2976 mL |
| 10 mM | 0.2649 mL | 1.3244 mL | 2.6488 mL |
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1.
