[CAS NO. 1092369-24-8] SLF-amido-C2-COOH

Name: SLF-amido-C2-COOH
Brand: Arctom Scientific
SKU: AS913324

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PRODUCTS SPECIFICATIONS [1092369-24-8]

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Catalog

AS913324

Brand

Arctom Scientific

CAS

1092369-24-8

DESCRIPTION [1092369-24-8]

Overview

MDL	-
Molecular Weight	624.72
Molecular Formula	C34H44N2O9
SMILES	O=C(O)CCC(NC1=CC=CC([C@H](OC([C@H]2N(C(C(C(C)(C)CC)=O)=O)CCCC2)=O)CCC3=CC=C(OC)C(OC)=C3)=C1)=O

For research use only. We do not sell to patients.

Summary

SLF-amido-C2-COOH (PROTAC FKBP12-binding moiety 1) is a synthetic ligand for FKBP (SLF). SLF-amido-C2-COOH (PROTAC FKBP12-binding moiety 1) can be used in the synthesis of PROTACs ^[1] .

In Vitro

SLF-amido-C2-COOH (PROTAC FKBP12-binding moiety 1) is a synthetic ligand for FKBP (SLF). SLF is composed of only one half of FK506 and it is known to have a significantly weaker affinity for FKBP12 ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 160.07 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6007 mL	8.0036 mL	16.0072 mL
5 mM	0.3201 mL	1.6007 mL	3.2014 mL
10 mM	0.1601 mL	0.8004 mL	1.6007 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (4.00 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 2.5 mg/mL (4.00 mM); Suspended solution; Need ultrasonic
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (4.00 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Dunyak BM, et al. Selective Targeting of Cells via Bispecific Molecules That Exploit Coexpression of TwoIntracellular Proteins. ACS Chem Biol. 2015 Nov 20;10(11):2441-7.