[CAS NO. 1093978-89-2] gamma-secretasemodulator2
PRODUCTS SPECIFICATIONS [1093978-89-2]
DESCRIPTION [1093978-89-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 514.47 |
| Molecular Formula | C25H22F4N6O2 |
| SMILES | O=C1N(C2=CC=CC(F)=C2CCC1N3N=NC(C4=CC(OC)=C(N5C=NC(C)=C5)C=C4)=C3)CC(F)(F)F |
Summary
gamma-secretase modulator 2 is a potent and selective γ-secretase modulator for treatment of Alzheimer's disease IC50 value: Target: γ-secretase γ-secretase modulator is modulation of the action of γ-secretase so as to Selectively attenuate production of Aβ(1-42) and hence find use in treatment or prevention of diseases associated with deposition of Aβ in the brain. γ-secretase modulator is usful in particular Alzheimer's disease.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 194.37 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.9437 mL | 9.7187 mL | 19.4375 mL |
| 5 mM | 0.3887 mL | 1.9437 mL | 3.8875 mL |
| 10 mM | 0.1944 mL | 0.9719 mL | 1.9437 mL |
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Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (4.86 mM); Clear solution
