[CAS NO. 109544-45-8] 2-Methoxyidazoxan monohydrochloride
PRODUCTS SPECIFICATIONS [109544-45-8]
DESCRIPTION [109544-45-8]
Overview
| MDL | MFCD00069343 |
|---|---|
| Molecular Weight | 270.71 |
| Molecular Formula | C12H15ClN2O3 |
| SMILES | COC1(C2=NCCN2)OC3=CC=CC=C3OC1.[H]Cl |
Summary
2-Methoxyidazoxan monohydrochloride (RX821002 hydrochloride) is a highly selective alpha 2-adrenoceptor antagonist with little or no imidazoline antagonist effect. RX 821002 has markedly higher affinity for (guinea-pig) alpha 2D-adrenoceptors (pK d 9.7) than for (rabbit) alpha 2A-adrenoceptors (pK d 8.2) [1] [2] .
In Vivo
2-Methoxyidazoxan monohydrochloride (1 mg/kg) enhances locomotion in the novel environment, particularly in neonatal ventral hippocampal lesion (NVHL) rats. RX82100 has a biphasic effect on locomotion, consisting of an initial reduction preceding the enhancement [3] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Solvent & Solubility
H 2 O : 100 mg/mL ( 369.40 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.6940 mL | 18.4699 mL | 36.9399 mL |
| 5 mM | 0.7388 mL | 3.6940 mL | 7.3880 mL |
| 10 mM | 0.3694 mL | 1.8470 mL | 3.6940 mL |
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1.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (184.70 mM); Clear solution; Need ultrasonic
References
- [1] Head GA. Importance of imidazoline receptors in the cardiovascular actions of centrally acting antihypertensive agents. Ann N Y Acad Sci. 1995;763:531-540.
- [2] Trendelenburg AU, et al. Antagonists that differentiate between alpha 2A-and alpha 2D-adrenoceptors. Naunyn Schmiedebergs Arch Pharmacol. 1996;353(3):245-249.
- [3] Sandner G, et al. Effects of caffeine or RX821002 in rats with a neonatal ventral hippocampal lesion. Front Behav Neurosci. 2014;8:15. Published 2014 Jan 28.
