[CAS NO. 113276-94-1] H-8dihydrochloride

Name: H-8dihydrochloride
Brand: Arctom Scientific
SKU: AS078749

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PRODUCTS SPECIFICATIONS [113276-94-1]

Distributor

Catalog

AS078749

Brand

Arctom Scientific

CAS

113276-94-1

DESCRIPTION [113276-94-1]

Overview

MDL	-
Molecular Weight	338.25
Molecular Formula	C12H17Cl2N3O2S
SMILES	O=S(C1=CC=CC2=C1C=CN=C2)(NCCNC)=O.Cl.Cl

For research use only. We do not sell to patients.

Summary

H-8 (dihydrochloride) is a cell-permeable, reversible and ATP-competitive PKA inhibitor ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 147.82 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9564 mL	14.7820 mL	29.5639 mL
5 mM	0.5913 mL	2.9564 mL	5.9128 mL
10 mM	0.2956 mL	1.4782 mL	2.9564 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (7.39 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (7.39 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (7.39 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Niisato N, et al. Effects of PKA inhibitors, H-compounds, on epithelial Na+ channels via PKA-independent mechanisms. Life Sci. 1999;65(10):PL109-14.

Synonyms

5-Isoquinolinesulfonamide, N-[2-(methylamino)ethyl]-, hydrochloride (1:2)

5-Isoquinolinesulfonamide, N-[2-(methylamino)ethyl]-, dihydrochloride

H 8

H 8 dihydrochloride

N-[2-(Methylamino)ethyl]isoquinoline-5-sulfonamide dihydrochloride