[CAS NO. 113852-37-2] Cidofovir

Name: Cidofovir
Brand: Arctom Scientific
SKU: AS181658

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PRODUCTS SPECIFICATIONS [113852-37-2]

Distributor

Catalog

AS181658

Brand

Arctom Scientific

CAS

113852-37-2

DESCRIPTION [113852-37-2]

Overview

MDL	MFCD00866936
Molecular Weight	279.19
Molecular Formula	C8H14N3O6P
SMILES	C([C@H](OCP(=O)(O)O)CO)N1C(=O)N=C(N)C=C1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.5818 mL	17.9090 mL	35.8179 mL
5 mM	0.7164 mL	3.5818 mL	7.1636 mL
10 mM	0.3582 mL	1.7909 mL	3.5818 mL
50 mM	-	-	-

Description

Cidofovir (HPMPC,Vistide,GS 0504) suppresses virus replication by selective inhibition of viral DNA synthesis.

In vitro

Cidofovir inhibits human cytomegalovirus (HCMV) infection in cultured cells. Cidofovir is inhibitory to CMV plaque formation even when added to the cells at 48 hr post infection with IC50 of 0.9 μg/mL for Davis and 1.6 μg/mL for AD-169 strains,respectively. Cidofovir also inhibits herpes simplex virus infection. In addition, Cidofovir blocks cell fusion induced by HSV-1 in monkey kidney cells and blocks the expression of HSV-l-specific proteins and the synthesis of viral DNA.

References

[1] Snoeck R, et al, Antimicrob Agents Chemother, 1988, 32(12), 1839-1844.
[2] Li SB, et al. Antiviral Res, 1990, 13(5), 237-252.
[3] Chatterjee S, et al. Antiviral Res., 1992, 19(3), 181-192.
[4] De Clercq E, et al. Antimicrob Agents Chemother, 1991, 35(4), 701-706.
[5] Redondo P, et al. Br J Dermatol, 2000, 143(4), 741-748.

Synonyms

Phosphonic acid, P-[[(1S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]-

Phosphonic acid, [[2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]-, (S)-

Phosphonic acid, [[(1S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]-

P-[[(1S)-2-(4-Amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]phosphonic acid

(S)-HPMPC

HPMPC

1-(S)-(3-Hydroxy-2-phosphonylmethoxypropyl)cytosine

1-[(S)-3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine

(S)-1-(3-hydroxy-2-phosphonomethoxypropyl)cytosine

GS 0504

Cidofovir

Vistide

Cidovir

Cidofovir monophosphate