[CAS NO. 115338-32-4] NAN-190hydrobromide

Name: NAN-190hydrobromide
Brand: Arctom Scientific
SKU: AS459047

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PRODUCTS SPECIFICATIONS [115338-32-4]

Distributor

Catalog

AS459047

Brand

Arctom Scientific

CAS

115338-32-4

DESCRIPTION [115338-32-4]

Overview

MDL	MFCD00078590
Molecular Weight	474.39
Molecular Formula	C23H28BrN3O3
SMILES	O=C1N(CCCCN2CCN(C3=CC=CC=C3OC)CC2)C(C4=C1C=CC=C4)=O.[H]Br

For research use only. We do not sell to patients.

Summary

NAN-190 hydrobromide is a serotonin receptor 5-HT antagonist. NAN-190 is a selective antagonist of 5-HT _1A ^[1] ^[3] .

IC50 & Target

5-HT ₁ Receptor

In Vivo

NAN-190 hydrobromide (0.5 mg/kg, ip) is injected concomitantly with the effective dose of fluoxetine. NAN-190 reverses the catalepsy-improving effect of fluoxetine in 6-OHDA lesioned rats ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 16.67 mg/mL ( 35.14 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1080 mL	10.5399 mL	21.0797 mL
5 mM	0.4216 mL	2.1080 mL	4.2159 mL
10 mM	0.2108 mL	1.0540 mL	2.1080 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 1.67 mg/mL (3.52 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 1.67 mg/mL (3.52 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-, hydrobromide (1:1)

1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-, monohydrobromide

2-[4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl]-1H-isoindole-1,3(2H)-dione hydrobromide (1:1)

NAN 190

2-(4-(4-(2-Methoxyphenyl)piperazin-1-yl)butyl)-isoindoline-1,3-dione hydrobromide