[CAS NO. 1158838-45-9] TCS7010
PRODUCTS SPECIFICATIONS [1158838-45-9]
DESCRIPTION [1158838-45-9]
Overview
| MDL | MFCD16495816 |
|---|---|
| Molecular Weight | 588.08 |
| Molecular Formula | C31H31ClFN7O2 |
| SMILES | O=C(C1=CC=C(C=C1)NC2=C(F)C=NC(NC3=CC=C(C=C3)CC(N4CCN(CC4)CC)=O)=N2)NC5=CC=CC=C5Cl |
2 Publications Citing Use of MCE
Summary
TCS7010 is a potent and highly selective Aurora A inhibitor with with an IC 50 of 3.4 nM.
IC50 & Target
|
Aurora A 3.4 nM (IC 50 ) |
Aurora B 3.4 μM (IC 50 ) |
In Vitro
TCS7010 is exceptionally selective Aurora A inhibitors. TCS7010 is an useful tool compounds for investigating the cellular role of Aurora A kinases without the complication of also inhibiting Aurora B [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 85.02 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.7004 mL | 8.5022 mL | 17.0045 mL |
| 5 mM | 0.3401 mL | 1.7004 mL | 3.4009 mL |
| 10 mM | 0.1700 mL | 0.8502 mL | 1.7004 mL |
-
1.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (4.25 mM); Clear solution
