[CAS NO. 1160247-92-6] VU0238429

Name: VU0238429
Brand: Arctom Scientific
SKU: AS893820

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [1160247-92-6]

Distributor

Catalog

AS893820

Brand

Arctom Scientific

CAS

1160247-92-6

DESCRIPTION [1160247-92-6]

Overview

MDL	MFCD16618396
Molecular Weight	351.28
Molecular Formula	C17H12F3NO4
SMILES	C(N1C=2C(C(=O)C1=O)=CC(OC(F)(F)F)=CC2)C3=CC=C(OC)C=C3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.8467 mL	14.2337 mL	28.4673 mL
5 mM	0.5693 mL	2.8467 mL	5.6935 mL
10 mM	0.2847 mL	1.4234 mL	2.8467 mL
50 mM	0.0569 mL	0.2847 mL	0.5693 mL

Description

VU0238429 (M5 PAM) is the first positive allosteric modulator of with EC50 of 1.16 μM at M5 and both > 30 μM at M1 and M3. VU0238429 shows no potentiator activity at M2 or M4.

Targets

M1 mAChR ^[1]	M3 mAChR ^[1]	M5 mAChR ^[1] (Cell-free assay)
		1.16 μM

References

[1] Bridges TM, et al. J Med Chem. 2009 Jun 11;52(11):3445-8.

Synonyms

1H-Indole-2,3-dione, 1-[(4-methoxyphenyl)methyl]-5-(trifluoromethoxy)-

1-[(4-Methoxyphenyl)methyl]-5-(trifluoromethoxy)-1H-indole-2,3-dione

VU 0238429

ML 129

1-(4-Methoxy-benzyl)-5-trifluoromethoxy-1H-indole-2,3-dione

HY 12157