[CAS NO. 1160514-60-2] Pyr3

Name: Pyr3
Brand: Arctom Scientific
SKU: AS937424

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PRODUCTS SPECIFICATIONS [1160514-60-2]

Fulfillment

Catalog

AS937424

Brand

Arctom Scientific

CAS

1160514-60-2

DESCRIPTION [1160514-60-2]

Overview

MDL	-
Molecular Weight	456.63
Molecular Formula	C16H11Cl3F3N3O3
SMILES	O=C(C1=C(C(F)(F)F)N(C2=CC=C(NC(/C(Cl)=C(Cl)/Cl)=O)C=C2)N=C1)OCC

For research use only. We do not sell to patients.

4 Publications Citing Use of MCE

Summary

Pyr3 is a selective inhibitor of transient receptor potential canonical channel 3 (TRPC3) , with an IC ₅₀ of 700 nM for TRPC3-mediated Ca ²⁺ influx.

IC50 & Target

IC50: 700 nM (TRPC3) ^[1] .

In Vitro

Pyr3 selectively and directly inhibits TRPC3 channels among TRPC family members. Application of Pyr3 inhibits TRPC3-mediated Ca ²⁺ influx in a dose-dependent manner with the IC ₅₀ value of 700 nM. Pyr3 becomes apparent at 0.3 μM, and is almost complete at 3 μM. Interestingly, Ca ²⁺ influx is inhibited by Pyr3 in cells co-expressing TRPC3 plus TRPC6 but not in cells coexpressing TRPC1 plus TRPC5. The Ang II-induced NFAT translocation is suppressed by Pyr3, but weakly by Pyr2 in a concentration-dependent manner (IC ₅₀ value was 0.05 μM for Pyr3 and 2 μM for Pyr2) ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 125 mg/mL ( 273.74 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1900 mL	10.9498 mL	21.8996 mL
5 mM	0.4380 mL	2.1900 mL	4.3799 mL
10 mM	0.2190 mL	1.0950 mL	2.1900 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (4.56 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (4.56 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (4.56 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Kiyonaka S, et al. Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5400-5.