[CAS NO. 117235-10-6]  3-MercaptopropionicacidNHSester

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PRODUCTS SPECIFICATIONS [117235-10-6]

Distributor
Catalog
AS894906
Brand
Arctom Scientific
CAS
117235-10-6

DESCRIPTION [117235-10-6]

Overview

MDLMFCD28964889
Molecular Weight203.22
Molecular FormulaC7H9NO4S
SMILESO=C(ON1C(CCC1=O)=O)CCS

For research use only. We do not sell to patients.

Summary

3-Mercaptopropanyl-N-hydroxysuccinimide ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs [1] .


IC50 & Target

Alkyl/ether


In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Appearance

Liquid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 492.08 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9208 mL 24.6039 mL 49.2078 mL
5 mM 0.9842 mL 4.9208 mL 9.8416 mL
10 mM 0.4921 mL 2.4604 mL 4.9208 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.5 mg/mL (12.30 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (12.30 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.5 mg/mL (12.30 mM); Clear solution

* All of the co-solvents are available by MCE.