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[CAS NO. 1174122-54-3]  Retagliptin

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PRODUCTS SPECIFICATIONS [1174122-54-3]

Distributor
Catalog
AS947366
Brand
Arctom Scientific
CAS
1174122-54-3

DESCRIPTION [1174122-54-3]

Overview

MDLMFCD22200238
Molecular Weight464.36
Molecular FormulaC19H18F6N4O3
SMILESO=C(C1=C2CN(C(C[C@H](N)CC3=CC(F)=C(F)C=C3F)=O)CCN2C(C(F)(F)F)=N1)OC

For research use only. We do not sell to patients.

Summary

Retagliptin (SP2086) is a selective, competitive and orally active dipeptidyl peptidase-4 (DPP-4) inhibitor. Retagliptin can be used for type 2 diabetes mellitus (T2DM) research [1] .


In Vitro

Retagliptin is a class of compound used for research of type 2 diabetes. Retagliptin inhibits the degradation of GLP-1, thus amplifying the incretin effect [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Clinical Trial

NCT Number Sponsor Condition Start Date Phase
NCT01969357 Jiangsu HengRui Medicine Co., Ltd.
Type 2 Diabetes
June 2011 Phase 2
NCT02821871 Jiangsu HengRui Medicine Co., Ltd.
Type 2 Diabetes
March 2016 Phase 1
NCT01970046 Jiangsu HengRui Medicine Co., Ltd.
Type 2 Diabetes
April 2013 Phase 3

Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 215.35 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1535 mL 10.7675 mL 21.5350 mL
5 mM 0.4307 mL 2.1535 mL 4.3070 mL
10 mM 0.2154 mL 1.0768 mL 2.1535 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.5 mg/mL (5.38 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.38 mM); Clear solution

  • 3.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.38 mM); Clear solution

* All of the co-solvents are available by MCE.


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