[CAS NO. 117423-74-2] LY223982
PRODUCTS SPECIFICATIONS [117423-74-2]
DESCRIPTION [117423-74-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 502.56 |
| Molecular Formula | C30H30O7 |
| SMILES | O=C(O)CCC1=CC(C(C2=CC=CC(C(O)=O)=C2)=O)=CC=C1OCCCC/C=C/C3=CC=C(OC)C=C3 |
Summary
LY223982 is a potent and specific inhibitor of leukotriene B4 receptor , with an IC 50 of 13.2 nM against [ 3 H]LTB4 binding to LTB4 receptor.
IC50 & Target
|
LTB 4 13.2 nM (IC 50 ) |
In Vitro
LY223982 is a potent and specific inhibitor of leukotriene B4 (LTB4) receptor, with an IC 50 of 13.2 nM against [3H]LTB4 binding to LTB4 receptor. LY223982 is also a potent antagonist of the aggregation of human neutrophils by LTB4 (IC 50 , 100 nM) [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
LY223982 inhibits transient leukopenia induced in rabbits with LTB4 (ED 50 , 3 mg/kg) but not with FMLP, and shows no agonist activity in any of the test systems [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 198.98 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.9898 mL | 9.9491 mL | 19.8981 mL |
| 5 mM | 0.3980 mL | 1.9898 mL | 3.9796 mL |
| 10 mM | 0.1990 mL | 0.9949 mL | 1.9898 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (4.97 mM); Clear solution
