[CAS NO. 1177600-74-6] SMANT hydrochloride

Name: SMANT hydrochloride
Brand: Arctom Scientific
SKU: AS561575

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PRODUCTS SPECIFICATIONS [1177600-74-6]

Distributor

Catalog

AS561575

Brand

Arctom Scientific

CAS

1177600-74-6

DESCRIPTION [1177600-74-6]

Overview

MDL	-
Molecular Weight	375.73
Molecular Formula	C16H24BrClN2O
SMILES	O=C(NC1=CC=C(Br)C=C1)CCN2CC(C)CC(C)C2.[H]Cl

For research use only. We do not sell to patients.

Summary

SMANT hydrochloride is a Smoothened ( Smo ) signaling inhibitor. SMANT hydrochloride is antagonist of Smo accumulation within the primary cilium (PC). SMANT hydrochloride has an equivalent activity in inhibiting SmoM2 (oncogenic form of Smo) and wild-type Smo ^[1] .

IC50 & Target

Smo, SmoM2 ^[1]

In Vitro

SMANT (0-10 μM, NIH/3T3 cells) hydrochloride inhibits Hh induced Smo accumulation at the primary cilium (IC ₅₀ : 1.1 μM) ^[1] .
SMANT (0-10 μM, NIH/3T3 cells) hydrochloride inhibits Smo and SmoM2 activity, and blocks the stimulatory action of SAG in Gli-luciferase assay ^[1] .
SMANT (0-10 μM) hydrochloride inhibits proliferation of cerebellar granule-cell neural progenitors (CGNP) (isolated from Ptch1 ^+/− neonates) induced by Shh ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

References

[1] Wang Y, et al. Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation. ACS Chem Biol. 2012 Jun 15;7(6):1040-8.