[CAS NO. 1181226-02-7] ZL006
PRODUCTS SPECIFICATIONS [1181226-02-7]
DESCRIPTION [1181226-02-7]
Overview
| MDL | MFCD20527326 |
|---|---|
| Molecular Weight | 328.15 |
| Molecular Formula | C14H11Cl2NO4 |
| SMILES | O=C(O)C1=CC=C(NCC2=CC(Cl)=CC(Cl)=C2O)C=C1O |
Summary
ZL006 is a potent inhibitor of nNOS/PSD-95 interaction, and inhibits NMDA receptor -mediated NO synthesis.
In Vitro
ZL006 presents little cytotoxicity, and a growth inhibition of BCECs is not found at low concentration of 0.001, 0.01, 0.1, 1 and 10 μg/mL. The cytotoxicity of T7-P-LPs/ZL006 is significantly enhanced at the concentration of 10 μg/mL. Cellular uptake of ZL006 loads P-LPs and T7-P-LPs after incubation for 0.5 h at the concentrations range from 100 μg/mL to 600 μg/mL in BCECs [1] . ZL006 does not inhibit the nNOS-PDZ/PSD-95-PDZ interaction, or perturb the nNOS β-finger [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Compared with P-LPs/ZL006 and free ZL006, T7-P-LPs/ZL006 exhibits a significant increase of drug accumulation in the brain tissue due to its better brain targeting delivery. Compared with free ZL006, P-LPs/ZL006 and T7-P-LPs/ZL006 exhibit a significant decrease of drug accumulation in the liver and kidney [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 29 mg/mL ( 88.37 mM )
H 2 O : < 0.1 mg/mL (insoluble)
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.0474 mL | 15.2369 mL | 30.4739 mL |
| 5 mM | 0.6095 mL | 3.0474 mL | 6.0948 mL |
| 10 mM | 0.3047 mL | 1.5237 mL | 3.0474 mL |
References
- [1] Wang Z, et al. Enhanced anti-ischemic stroke of ZL006 by T7-conjugated PEGylated liposomes drug delivery system. Sci Rep. 2015 Jul 29;5:12651.
- [2] Bach A, et al. Biochemical investigations of the mechanism of action of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ/PSD-95-PDZ interactions. Sci Rep. 2015 Jul 16;5:12157.
