[CAS NO. 1200365-63-4]  Aminooxy-PEG3-C2-thiol

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PRODUCTS SPECIFICATIONS [1200365-63-4]

Catalog
AS940611
Brand
Arctom Scientific
CAS
1200365-63-4

DESCRIPTION [1200365-63-4]

Overview

MDLMFCD29918250
Molecular Weight225.31
Molecular FormulaC8H19NO4S
SMILESNOCCOCCOCCOCCS

For research use only. We do not sell to patients.

Summary

Aminooxy-PEG3-C2-thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1] .


IC50 & Target

PEGs


In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 443.83 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4383 mL 22.1916 mL 44.3833 mL
5 mM 0.8877 mL 4.4383 mL 8.8767 mL
10 mM 0.4438 mL 2.2192 mL 4.4383 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.5 mg/mL (11.10 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (11.10 mM); Clear solution

  • 3.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.5 mg/mL (11.10 mM); Clear solution

* All of the co-solvents are available by MCE.