[CAS NO. 1208313-97-6] Ketonemonoester
PRODUCTS SPECIFICATIONS [1208313-97-6]
DESCRIPTION [1208313-97-6]
Overview
| MDL | MFCD22417094 |
|---|---|
| Molecular Weight | 176.21 |
| Molecular Formula | C8H16O4 |
| SMILES | C[C@@H](O)CC(OCC[C@H](O)C)=O |
Summary
(R,R)-BD-AcAc 2 ((R,R)-Ketone Ester), a ketone monoester, can be used as a source of oral nutritional ketones. (R,R)-BD-AcAc 2 can elevate plasma levels of β-hydroxybutyrate and acetoacetate, blood glucose, blood Na + levels and blood creatinine levels after oral administration in mice. (R,R)-BD-AcAc 2 can partly prevent muscle weakness in septic mice. (R,R)-BD-AcAc 2 has potential to improve exercise performance and endurance in animal body. (R,R)-BD-AcAc 2 can also be used to research Parkinson’s disease or diabetes [1] [2] [3] .
In Vivo
(R,R)-BD-AcAc 2 (D-3HHB) increases specific muscle force, moderately raises blood glucose concentrations, lowers Aldh3b2 gene expression, increases blood Na + levels and blood creatinine levels, and reduces plasma free fatty acid concentrations [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Septic mice [1] |
| Dosage: | 10, 20, 40 and 80 mmol/kg/day |
| Administration: | PO |
| Result: |
Increased specific muscle force as compared with placebo to 93% of healthy control levels at 40 mmol/kg/day.
Resulted in moderately higher blood glucose concentrations as compared with placebo at 40 mmol/kg/day. Lowered Aldh3b2 gene expression than with placebo at 40 mmol/kg/day. Evoked a moderate further increase in blood Na + levels and increased blood creatinine levels at 20 mmol/kg/day. Reduced plasma free fatty acid concentrations by 10 or 20 mmol/kg/day. Hepatic gene expression levels of Aldh1a7 was also reduced by sepsis but increased by D-3HHB. |
Appearance
Liquid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Pure form | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
H 2 O : 100 mg/mL ( 567.50 mM ; Need ultrasonic)
DMSO : 100 mg/mL ( 567.50 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 5.6750 mL | 28.3752 mL | 56.7505 mL |
| 5 mM | 1.1350 mL | 5.6750 mL | 11.3501 mL |
| 10 mM | 0.5675 mL | 2.8375 mL | 5.6750 mL |
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1.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (567.50 mM); Clear solution; Need ultrasonic
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2.
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3.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 5.5 mg/mL (31.21 mM); Clear solution
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4.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 5.5 mg/mL (31.21 mM); Clear solution
References
- [1] Weckx R, et al. Efficacy and safety of ketone ester infusion to prevent muscle weakness in a mouse model of sepsis-induced critical illness. Sci Rep. 2022 Jun 22;12(1):10591.
- [2] Williams MS, et al. The Chemistry of the Ketogenic Diet: Updates and Opportunities in Organic Synthesis. Int J Mol Sci. 2021 May 15;22(10):5230.
- [3] Clarke K, et al. Oral 28-day and developmental toxicity studies of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate. Regul Toxicol Pharmacol. 2012 Jul;63(2):196-208.
Synonyms
