[CAS NO. 121288-39-9] Loxoribine
PRODUCTS SPECIFICATIONS [121288-39-9]
DESCRIPTION [121288-39-9]
Overview
| MDL | MFCD00867591 |
|---|---|
| Molecular Weight | 339.30 |
| Molecular Formula | C13H17N5O6 |
| SMILES | O=C1N([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C3=C(C(NC(N)=N3)=O)N1CC=C |
Summary
Loxoribine (7-Allyl-8-oxoguanosine) is a guanosine analog with anti-viral and anti-tumor activities. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist [1] [2] [3] .
IC50 & Target
TLR7 [1]
In Vitro
Loxoribine induces maturation of human monocyte-derived dendritic cells DCs and stimulates their Th-1- and Th-17-polarizing capability
[2]
.
Loxoribine (250 μM; 48 hours) stimulates maturation of MoDCs as shown by up-regulation of CD80, CD83, CD40, CD54 and CCR7
[2]
.
loxoribine activates cells of the innate immune system selectively via the Toll-like receptor (TLR) 7/MyD88-dependent signaling pathway
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Loxoribine (2 mg; s.c.or i.v.) activates murine natural killer (NK) cells in vivo
[3]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | 8-12 weeks male CBA/J mice [3] |
| Dosage: | 2 mg |
| Administration: | Subcutaneous or intravenous injection |
| Result: | activates murine natural killer (NK) cells in vivo. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 294.72 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.9472 mL | 14.7362 mL | 29.4724 mL |
| 5 mM | 0.5894 mL | 2.9472 mL | 5.8945 mL |
| 10 mM | 0.2947 mL | 1.4736 mL | 2.9472 mL |
References
- [1] Heil F, et al. The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur J Immunol. 2003 Nov;33(11):2987-97.
- [2] Dzopalic T, et al. Loxoribine, a selective Toll-like receptor 7 agonist, induces maturation of human monocyte-derived dendritic cells and stimulates their Th-1- and Th-17-polarizing capability. Int Immunopharmacol. 2010 Nov;10(11):1428-33.
- [3] Pope BL, et al. In vivo enhancement of murine natural killer cell activity by 7-allyl-8-oxoguanosine (loxoribine). Int J Immunopharmacol. 1992 Nov;14(8):1375-82.
Synonyms
