[CAS NO. 1222781-70-5] ML133 hydrochloride
PRODUCTS SPECIFICATIONS [1222781-70-5]
DESCRIPTION [1222781-70-5]
Overview
| MDL | MFCD20921521 |
|---|---|
| Molecular Weight | 313.82 |
| Molecular Formula | C19H20ClNO |
| SMILES | COC1=CC=C(CNCC2=C3C=CC=CC3=CC=C2)C=C1.[H]Cl |
2 Publications Citing Use of MCE
Summary
ML133 hydrochloride is a selective K ir 2 family channels inhibitor, with an IC 50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5 [1] .
IC50 & Target
IC50: 1.8 μM (K ir 2 at pH 7.4), 290 nM (K ir 2 at pH 8.5) [1] .
In Vitro
ML133, which inhibits K
ir
2.1 with IC
50
of 1.8 μM at pH 7.4 and 290 nM at pH 8.5, but exhibits little selectivity against other members of K
ir
2.x family channels
[1]
.
ML133 has no effect on K
ir
1.1 (IC
50
> 300 μM), and displays weak activity for K
ir
4.1 (76 μM) and K
ir
7.1 (33 μM), making ML133 the most selective small molecule inhibitor of the Kir family reported to date
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL ( 318.65 mM ; ultrasonic and warming and heat to 60°C)
H 2 O : < 0.1 mg/mL (insoluble)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.1865 mL | 15.9327 mL | 31.8654 mL |
| 5 mM | 0.6373 mL | 3.1865 mL | 6.3731 mL |
| 10 mM | 0.3187 mL | 1.5933 mL | 3.1865 mL |
