[CAS NO. 1222810-74-3] VU591
PRODUCTS SPECIFICATIONS [1222810-74-3]
DESCRIPTION [1222810-74-3]
Overview
| MDL | MFCD20264924 |
|---|---|
| Molecular Weight | 368.30 |
| Molecular Formula | C16H12N6O5 |
| SMILES | O=[N+]([O-])C1=CC(NC(COCC2=NC3=C(N2)C=C([N+]([O-])=O)C=C3)=N4)=C4C=C1 |
Summary
VU591 is a potent, selective renal outer medullary potassium channel (ROMK or Kir1.1) inhibitor, with an IC 50 of 0.24 μM. VU591 can be used for neurological research with HY-108585 (the equivalent of VU591 hydrochloride) [1] .
IC50 & Target
IC50: 0.24 μM (ROMK) [1] .
In Vitro
VU591 is a selective ROMK inhibitor and a ROMK channel pore blocker. VU591 can bind serum protein and has high metabolic stability [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
VU591 (i.c.v.; 1.842 μg) significantly decreases the immobile time in TST [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Male ICR mice [2] |
| Dosage: | 1.842 μg |
| Administration: | i.c.v.; 1.842 μg; |
| Result: | Showed antidepressive effect in the tail suspension test (TST). |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 62.5 mg/mL ( 169.70 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.7152 mL | 13.5759 mL | 27.1518 mL |
| 5 mM | 0.5430 mL | 2.7152 mL | 5.4304 mL |
| 10 mM | 0.2715 mL | 1.3576 mL | 2.7152 mL |
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1.
References
- [1] Bhave G, et al. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol. 2011 Jan;79(1):42-50.
- [2] Masayoshi Okada, et al. Antidepressive effect of an inward rectifier K+ channel blocker peptide, tertiapin-RQ. PLoS One. 2020 Nov 13;15(11):e0233815.
