[CAS NO. 1222998-36-8] Torin1

Name: Torin1
Brand: Arctom Scientific
SKU: AS937026

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [1222998-36-8]

Fulfillment

Catalog

AS937026

Brand

Arctom Scientific

CAS

1222998-36-8

DESCRIPTION [1222998-36-8]

Overview

MDL	MFCD18782653
Molecular Weight	607.62
Molecular Formula	C35H28F3N5O2
SMILES	O=C1N(C2=C(C=C1)C=NC3=CC=C(C=C32)C4=CC5=CC=CC=C5N=C4)C6=CC=C(C(C(F)(F)F)=C6)N7CCN(CC7)C(CC)=O

For research use only. We do not sell to patients.

43 Publications Citing Use of MCE

Summary

Torin 1 is a potent inhibitor of mTOR with an IC ₅₀ of 3 nM. Torin 1 inhibits both mTORC1 / 2 complexes with IC ₅₀ values between 2 and 10 nM. Torin 1 is an effective inducer of autophagy .

IC50 & Target

mTOR

3 nM (IC ₅₀ )

mTORC1

2-10 nM (IC ₅₀ )

mTORC2

2-10 nM (IC ₅₀ )

ATM

0.6 μM (IC ₅₀ )

DNA-PK

1 μM (IC ₅₀ )

PI3K-α

1.8 μM (IC ₅₀ )

hVps34

3 μM (IC ₅₀ )

Autophagy

In Vitro

Torin1 (250 nM) completely inhibits proliferation and causes a G1/S cell cycle arrest, and decreases cell size to a greater degree than 50 nM rapamycin in wild-type MEFs ^[1] . Torin1 has more than 800-fold selectivity between mTOR and PI3Kis, and is very selective relative to other PIKK family kinases with the exception of DNA-PK ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Torin1 (20 mg/kg, i.p.) is efficacious in a U87MG xenograft model, and demonstrates good pharmacodynamic inhibition of downstream effectors of mTOR in tumor and peripheral tissues ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 2 mg/mL ( 3.29 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6458 mL	8.2288 mL	16.4577 mL
5 mM	---	---	---
10 mM	---	---	---

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 5% DMSO >> 40% PEG300 >> 5% Tween-80 >> 50% saline

Solubility: ≥ 0.25 mg/mL (0.41 mM); Clear solution
2.

Add each solvent one by one: 5% DMSO >> 95% (20% SBE-β-CD in saline)

Solubility: ≥ 0.25 mg/mL (0.41 mM); Clear solution
3.

Add each solvent one by one: 1% DMSO >> 99% saline

Solubility: 0.05 mg/mL (0.08 mM); Suspended solution; Need ultrasonic

* All of the co-solvents are available by MCE.