[CAS NO. 1225383-33-4] E3ligaseLigand8

Name: E3ligaseLigand8
Brand: Arctom Scientific
SKU: AS894330

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PRODUCTS SPECIFICATIONS [1225383-33-4]

Distributor

Catalog

AS894330

Brand

Arctom Scientific

CAS

1225383-33-4

DESCRIPTION [1225383-33-4]

Overview

MDL	-
Molecular Weight	530.61
Molecular Formula	C31H34N2O6
SMILES	CC(C)C[C@@H](C(O)=O)NC([C@@H](O)[C@H](NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)CC4=CC=CC=C4)=O

For research use only. We do not sell to patients.

2 Publications Citing Use of MCE

Summary

E3 ligase Ligand 8 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 8 can be connected to the ligand for protein by a linker to form PROTACs . PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 188.46 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8846 mL	9.4231 mL	18.8462 mL
5 mM	0.3769 mL	1.8846 mL	3.7692 mL
10 mM	0.1885 mL	0.9423 mL	1.8846 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (4.71 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575.