[CAS NO. 1233082-79-5] Ampkinone
PRODUCTS SPECIFICATIONS [1233082-79-5]
DESCRIPTION [1233082-79-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 505.52 |
| Molecular Formula | C31H23NO6 |
| SMILES | O=C1N(C2=CC=C(C(C3=CC=CC=C3)=O)C=C2)C(C4=C1C=CC5=C4C(C)(C)OC6=C(O)C(OC)=CC=C65)=O |
1 Publications Citing Use of MCE
Summary
Ampkinone is an indirect AMP-activated protein kinase ( AMPK ) activator.
IC50 & Target
|
AMPK |
In Vitro
Ampkinone stimulates the phosphorylation of AMPK via the indirect activation of AMPK in various cell lines. Ampkinone-mediated activation of AMPK requires the activity of LKB1 and results in increased glucose uptake inmuscle cells [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Ampkinone-treated DIO mice significantly reduce total body weight and overall fat mass. Histological examination and measurement of lipid parameters show that Ampkinone effectively improves metabolic abnormalities in the DIO mice model [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 98.91 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.9782 mL | 9.8908 mL | 19.7816 mL |
| 5 mM | 0.3956 mL | 1.9782 mL | 3.9563 mL |
| 10 mM | 0.1978 mL | 0.9891 mL | 1.9782 mL |
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