[CAS NO. 1234479-76-5] ERK5-IN-1

Name: ERK5-IN-1
Brand: Arctom Scientific
SKU: AS939439

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [1234479-76-5]

Distributor

Catalog

AS939439

Brand

Arctom Scientific

CAS

1234479-76-5

DESCRIPTION [1234479-76-5]

Overview

MDL	MFCD18642659
Molecular Weight	459.54
Molecular Formula	C25H29N7O2
SMILES	O=C1C2=C(C=CC=C2)N(C)C3=NC(NC4=C(OC)C=C(N5CCN(C)CC5)C=C4)=NC=C3N1C

For research use only. We do not sell to patients.

Summary

ERK5-IN-1 is a potent ERK5 inhibitor with an IC ₅₀ of 87±7 nM. ERK5-IN-1 also inhibits LRRK2 [G2019S] with an IC ₅₀ of 26 nM.

IC50 & Target

ERK5

87 nM (IC ₅₀ )

LRRK2[G2019S]

26 nM (IC ₅₀ )

In Vitro

ERK5-IN-1 (Compound 5) exhibits a cellular EC ₅₀ for inhibiting epidermal growth factor (EGF) induced ERK5 autophosphorylation of 0.19±0.04 μM ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL ( 217.61 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1761 mL	10.8804 mL	21.7609 mL
5 mM	0.4352 mL	2.1761 mL	4.3522 mL
10 mM	0.2176 mL	1.0880 mL	2.1761 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.75 mg/mL (5.98 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.75 mg/mL (5.98 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.75 mg/mL (5.98 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Deng X, et al. Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones. Eur J Med Chem. 2013;70:758-767.