[CAS NO. 1254044-38-6] Mito-apocynin(C11)
PRODUCTS SPECIFICATIONS [1254044-38-6]
DESCRIPTION [1254044-38-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 663.62 |
| Molecular Formula | C37H44BrO4P |
| SMILES | O=C(OCCCCCCCCCCC[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)C4=CC=C(O)C(OC)=C4.[Br-] |
1 Publications Citing Use of MCE
Summary
Mito-apocynin (C11), an orally active mitochondria-targeted triphenylphosphonium (TPP)-based compound, is synthesized by conjugating the Apocynin moiety with a TPP + cation. Mito-apocynin (C11) selectively targets mitochondria, and shows neuroprotective effect. Mito-apocynin (C11) prevents hyposmia and corrects deficits in motor function [1] .
In Vivo
Mito-apocynin-C11 (3 mg/kg; oral gavage; 3x/wk from 3 months of age until 15 months) markedly improves the coordinated motor function and olfactory function in LRRK2R1441G mice [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | LRRK2R1441G mice [1] |
| Dosage: | 3 mg/kg |
| Administration: | Oral gavage; 3x/wk from 3 months of age until 15 months |
| Result: | Markedly improved the coordinated motor function and olfactory function. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL ( 150.69 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.5069 mL | 7.5344 mL | 15.0689 mL |
| 5 mM | 0.3014 mL | 1.5069 mL | 3.0138 mL |
| 10 mM | 0.1507 mL | 0.7534 mL | 1.5069 mL |
