[CAS NO. 1256448-47-1] Nanatinostat

Name: Nanatinostat
Brand: Arctom Scientific
SKU: AS929818

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PRODUCTS SPECIFICATIONS [1256448-47-1]

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Catalog

AS929818

Brand

Arctom Scientific

CAS

1256448-47-1

MDL	-
Molecular Weight	394.40
Molecular Formula	C20H19FN6O2
SMILES	FC(C=C1)=CC(C=C2)=C1N=C2CN[C@H]3[C@@]4([H])[C@]3([H])CN(C5=NC=C(C(NO)=O)C=N5)C4

For research use only. We do not sell to patients.

Nanatinostat (CHR-3996) is a potent, class I selective and orally active histone deacetylase (HDAC) inhibitor with an IC ₅₀ of 8 nM ^[1] .

IC50：8 nM ( HDAC) ^[1]

NCT Number	Sponsor	Condition	Start Date	Phase
NCT00697879	Chroma Therapeutics	Solid Tumor	February 2008	Phase 1
NCT05166577	Viracta Therapeutics, Inc.	Nasopharyngeal Carcinoma\|EBV-Related Gastric Carcinoma\|EBV-Related Leiomyosarcoma\|EBV Related Carcinoma\|EBV-Related Sarcoma	October 7, 2021	Phase 1\|Phase 2
NCT05011058	Viracta Therapeutics, Inc.	Epstein-Barr Virus Associated Lymphoproliferative Disorder\|EBV-Related PTLD\|EBV Related Non-Hodgkin´s Lymphoma\|Extranodal NK+T-cell Lymphoma\|EBV-Positive DLBCL, Nos\|EBV Associated Lymphoma\|EBV-Related Hodgkin Lymphoma\|EBV Related PTCL, Nos	May 28, 2021	Phase 2

Solid

Room temperature in continental US; may vary elsewhere.

-20°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

In Vitro:

DMSO : 33.33 mg/mL ( 84.51 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (6.34 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: 2.5 mg/mL (6.34 mM); Suspended solution; Need ultrasonic

* All of the co-solvents are available by MCE.