[CAS NO. 1259933-16-8] Funapide

Name: Funapide
Brand: Arctom Scientific
SKU: AS943377

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PRODUCTS SPECIFICATIONS [1259933-16-8]

Distributor

Catalog

AS943377

Brand

Arctom Scientific

CAS

1259933-16-8

DESCRIPTION [1259933-16-8]

Overview

MDL	MFCD28502435
Molecular Weight	429.35
Molecular Formula	C22H14F3NO5
SMILES	O=C([C@]12COC3=C1C=C(OCO4)C4=C3)N(CC5=CC=C(C(F)(F)F)O5)C6=C2C=CC=C6

For research use only. We do not sell to patients.

Summary

Funapide (TV 45070; XEN402) is a potent Sodium Channel Nav1.7 inhibitor.

IC50 & Target

Na _v 1.7

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT02365636	Teva Branded Pharmaceutical Products R&D, Inc.	Postherpetic Neuralgia	February 26, 2015	Phase 2
NCT02215941	Teva Branded Pharmaceutical Products R&D, Inc.	Pharmacokinetics	August 2014	Phase 1
NCT02068599	Teva Branded Pharmaceutical Products R&D, Inc.	Osteoarthritis of the Knee	April 14, 2014	Phase 2

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL ( 465.82 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3291 mL	11.6455 mL	23.2910 mL
5 mM	0.4658 mL	2.3291 mL	4.6582 mL
10 mM	0.2329 mL	1.1646 mL	2.3291 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 5.25 mg/mL (12.23 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 5.25 mg/mL (12.23 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Price N , et al. Safety and Efficacy of a Topical Sodium Channel Inhibitor (TV-45070) in Patients With Postherpetic Neuralgia (PHN): A Randomized, Controlled, Proof-of-Concept, Crossover Study, With a Subgroup Analysis of the Nav1.7 R1150W Genotype. Clin

Synonyms

Spiro[furo[2,3-f]-1,3-benzodioxole-7(6H),3′-[3H]indol]-2′(1′H)-one, 1′-[[5-(trifluoromethyl)-2-furanyl]methyl]-, (3′S)-

(3′S)-1′-[[5-(Trifluoromethyl)-2-furanyl]methyl]spiro[furo[2,3-f]-1,3-benzodioxole-7(6H),3′-[3H]indol]-2′(1′H)-one

Funapide

(7S)-1′-[[5-(Trifluoromethyl)furan-2-yl]methyl]spiro[6H-furo[2,3-f][1,3]benzodioxole-7,3′-indole]-2′-one

(7S)-1′-[[5-(Trifluoromethyl)furan-2-yl]methyl]spiro[furo[2,3-f][1,3]benzodioxole-7,3′-indol]-2′(1′H)-one