[CAS NO. 1268244-85-4] trans-PX20606

Name: trans-PX20606
Brand: Arctom Scientific
SKU: AS904618

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PRODUCTS SPECIFICATIONS [1268244-85-4]

Distributor

Catalog

AS904618

Brand

Arctom Scientific

CAS

1268244-85-4

DESCRIPTION [1268244-85-4]

Overview

MDL	-
Molecular Weight	554.85
Molecular Formula	C29H22Cl3NO4
SMILES	O=C(O)C1=CC=C([C@H]2[C@H](C3=CC=C(OCC4=C(C5CC5)ON=C4C6=C(Cl)C=CC=C6Cl)C=C3Cl)C2)C=C1

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Arch Toxicol. 2022 Mar 10.

Summary

PX20606 trans racemate (PX-102 trans racemate) is a FXR agonist with EC ₅₀ s of 32 and 34 nM for FXR in FRET and M1H assay, respectively ^[1] .

IC50 & Target

EC50: 32 nM (FXR in FRET assay), 34 nM (FXR in M1H assay) ^[1]

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 180.23 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8023 mL	9.0114 mL	18.0229 mL
5 mM	0.3605 mL	1.8023 mL	3.6046 mL
10 mM	0.1802 mL	0.9011 mL	1.8023 mL

* Please refer to the solubility information to select the appropriate solvent.

References

[1] Kinzel O, et al. Novel substituted isoxazole FXR agonists with cyclopropyl, hydroxycyclobutyl and hydroxyazetidinyl linkers: Understanding and improving key determinants of pharmacological properties. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3746-53.