[CAS NO. 1273323-67-3] YLF-466D
PRODUCTS SPECIFICATIONS [1273323-67-3]
DESCRIPTION [1273323-67-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 465.93 |
| Molecular Formula | C29H20ClNO3 |
| SMILES | O=C(O)C1=CC=CC(CN2C(/C(C3=C2C=CC=C3)=C(C4=CC=C(Cl)C=C4)\C5=CC=CC=C5)=O)=C1 |
2 Publications Citing Use of MCE
Summary
YLF-466D is a newly developed AMPK activator, which inhibits platelet aggregation.
IC50 & Target
|
AMPK |
In Vitro
The effect of YLF-466D on platelet AMPK and aggregation are examined to test whether YLF-466D can stimulate AMPK in platelets and thereby suppress aggregation. Platelet AMPK is activated by YLF-466D, which is confirmed with activation-dependent phosphorylation at Thr172. Consistent with this result, YLF-466D inhibits platelet aggregation induced by thrombin. Such inhibition is observed in the aggregation elicited by ADP and collagen as well as thrombin, indicating that the antiaggregatory effect of YLF-466D is not platelet-agonist specific but common, regardless of agonist type. All the effects on AMPK and aggregation are concentration-dependent with the highest efficacy at 150 μM. IC 50 against thrombin-, ADP- and collagen-induced aggreation are approximately 84, 55 and 87 μM, respectively [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 100 mg/mL ( 214.62 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.1462 mL | 10.7312 mL | 21.4625 mL |
| 5 mM | 0.4292 mL | 2.1462 mL | 4.2925 mL |
| 10 mM | 0.2146 mL | 1.0731 mL | 2.1462 mL |
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Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (5.37 mM); Clear solution
