[CAS NO. 1279829-87-6] SGK1-IN-1
PRODUCTS SPECIFICATIONS [1279829-87-6]
DESCRIPTION [1279829-87-6]
Overview
| MDL | MFCD28359117 |
|---|---|
| Molecular Weight | 418.83 |
| Molecular Formula | C17H12ClFN6O2S |
| SMILES | O=S(C1=C(F)C=CC(Cl)=C1)(NC2=CC=C(C3=NC(NN=C4N)=C4N=C3)C=C2)=O |
Summary
SGK1-IN-1 is a highly active and selective inhibitor of SGK-1 , with an IC 50 of 1 nM.
In Vitro
SGK1-IN-1 (14n) shows an acceptable SGK isoform selectivity with a good activity on hSGK2 and a moderate activity on the hSGK3, with IC 50 s of 1, 41 nM at 10 μM and 50 μM ATP concentration, respectively. SGK1-IN-1 also displays cellular activity in a SGK1-dependent phosphorylation of GSK3β assay in U2OS cells with activities of 0.69 μM [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 119.38 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.3876 mL | 11.9380 mL | 23.8760 mL |
| 5 mM | 0.4775 mL | 2.3876 mL | 4.7752 mL |
| 10 mM | 0.2388 mL | 1.1938 mL | 2.3876 mL |
-
1.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (5.97 mM); Clear solution
References
