[CAS NO. 129277-38-9] Lobetyolin

Name: Lobetyolin
Brand: Arctom Scientific
SKU: AS186046

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PRODUCTS SPECIFICATIONS [129277-38-9]

Distributor

Catalog

AS186046

Brand

Arctom Scientific

CAS

129277-38-9

DESCRIPTION [129277-38-9]

Overview

MDL	MFCD09953797
Molecular Weight	396.43
Molecular Formula	C20H28O8
SMILES	O[C@H](C#CC#C/C=C/C)[C@@H](/C=C/CCCO)O[C@@H]([C@@H]([C@H]1O)O)O[C@@H]([C@H]1O)CO

For research use only. We do not sell to patients.

Summary

Lobetyolin, a bioactive compound, is derived from Codonopsis pilosula . Lobetyolin has anti-inflammatory, anti-oxidative and xanthine oxidase inhibiting activities. Lobetyolin also induces the apoptosis via the inhibition of ASCT2 -mediated glutamine metabolism ^[1] ^[2] .

In Vitro

Lobetyolin is derived from Codonopsis pilosula and has antioxidative effect. MUC5AC gene expression induced by phorbol 12-myristate 13-acetate (PMA) from NCI-H292 cells is inhibited by pretreatment with Lobetyolin, lobetyol or methyl linoleate. Lobetyolin does not affect PMA-induced MUC5AC production from NCI-H292 cells. The amounts of mucin in the cells of Lobetyolin-treated cultures are 100±25%, 487±33%, 524±38%, 411±24%, and 402±45% for control, 10 ng/mL of PMA alone, PMA plus Lobetyolin 1 μM, PMA plus Lobetyolin 10 μM, and PMA plus Lobetyolin 100 μM, respectively ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 126.13 mM ; Need ultrasonic)

H ₂ O : 50 mg/mL ( 126.13 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5225 mL	12.6126 mL	25.2251 mL
5 mM	0.5045 mL	2.5225 mL	5.0450 mL
10 mM	0.2523 mL	1.2613 mL	2.5225 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: PBS

Solubility: 33.33 mg/mL (84.08 mM); Clear solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (6.31 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (6.31 mM); Clear solution
4.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (6.31 mM); Clear solution

* All of the co-solvents are available by MCE.