[CAS NO. 130581-13-4] Eplivanserin (mixture)

Name: Eplivanserin (mixture)
Brand: Arctom Scientific
SKU: AS937419

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PRODUCTS SPECIFICATIONS [130581-13-4]

Distributor

Catalog

AS937419

Brand

Arctom Scientific

CAS

130581-13-4

DESCRIPTION [130581-13-4]

Overview

MDL	-
Molecular Weight	328.38
Molecular Formula	C19H21FN2O2
SMILES	OC1=CC=C(/C=C/C(C2=CC=CC=C2F)=N/OCCN(C)C)C=C1

For research use only. We do not sell to patients.

Summary

Eplivanserin mixture (SR-46349 mixture) is a selective serotonin reuptake inhibitor and a 5-HT _2A receptor antagonist, extracted from patent WO 2005/002578 A1 ^[1] .

IC50 & Target

5-HT _2A Receptor

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years

* The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL ( 380.66 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0453 mL	15.2263 mL	30.4525 mL
5 mM	0.6091 mL	3.0453 mL	6.0905 mL
10 mM	0.3045 mL	1.5226 mL	3.0453 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (6.33 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (6.33 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (6.33 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] BERMAN, Robert, Mark, et al. COMPOSITIONS CONTAINING A SEROTONIN SELECTIVE REUPTAKE INHIBITOR AND A 5-HT2A RECEPTOR ANTAGONIST. WO 2005/002578 A1.