[CAS NO. 130717-51-0] FR122047

Name: FR122047
Brand: Arctom Scientific
SKU: AS112159

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [130717-51-0]

Distributor

Catalog

AS112159

Brand

Arctom Scientific

CAS

130717-51-0

DESCRIPTION [130717-51-0]

Overview

MDL	-
Molecular Weight	459.99
Molecular Formula	C23H26ClN3O3S
SMILES	O=C(C1=NC(C2=CC=C(OC)C=C2)=C(C3=CC=C(OC)C=C3)S1)N4CCN(C)CC4.[H]Cl

For research use only. We do not sell to patients.

Summary

FR122047 (hydrochloride) is a selective and oral active inhibitor of COX-1 with an IC ₅₀ of 28 nM. FR122047 hydrochloride has antiplatelet, analgesic and anti-inflammatory effects in vivo ^[1] ^[2] ^[3] .

IC50 & Target

COX-1

28 nM (IC ₅₀ )

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 217.40 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1740 mL	10.8698 mL	21.7396 mL
5 mM	0.4348 mL	2.1740 mL	4.3479 mL
10 mM	0.2174 mL	1.0870 mL	2.1740 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% Saline

Solubility: 2.5 mg/mL (5.43 mM); Clear solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in Saline)

Solubility: 2.5 mg/mL (5.43 mM); Clear solution; Need ultrasonic

* All of the co-solvents are available by MedChemExpress (MCE).