[CAS NO. 1334850-99-5] Mito-TEMPO

Name: Mito-TEMPO
Brand: Arctom Scientific
SKU: AS893846

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PRODUCTS SPECIFICATIONS [1334850-99-5]

Distributor

Catalog

AS893846

Brand

Arctom Scientific

CAS

1334850-99-5

DESCRIPTION [1334850-99-5]

Overview

MDL	MFCD26406410
Molecular Weight	510.03
Molecular Formula	C29H35ClN2O2P
SMILES	[O]N1C(C)(C)CC(NC(C[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)=O)CC1(C)C.[Cl-]

For research use only. We do not sell to patients.

22 Publications Citing Use of MCE

Summary

Mito-TEMPO is a mitochondria-targeted superoxide dismutase mimetic with superoxide and alkyl radical scavenging properties ^[1] .

In Vivo

Mito-TEMPO (MT) greatly attenuates the increase in ALT activities and reduces the areas of necrosis at both time points, indicating that the protection by Mito-TEMPO is sustained until at least 24 h post-APAP. Mito-Tempo could induce secondary apoptosis in the late phase of APAP hepatotoxicity. Mito-Tempo induces secondary apoptosis after APAP overdose by inhibition of RIP3 ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL ( 245.08 mM ; Need ultrasonic)

H ₂ O : 60 mg/mL ( 117.64 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9607 mL	9.8033 mL	19.6067 mL
5 mM	0.3921 mL	1.9607 mL	3.9213 mL
10 mM	0.1961 mL	0.9803 mL	1.9607 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: PBS

Solubility: 50 mg/mL (98.03 mM); Clear solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.25 mg/mL (4.41 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.25 mg/mL (4.41 mM); Clear solution
4.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.25 mg/mL (4.41 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Du K, et al. Mito-tempo protects against acute liver injury but induces limited secondary apoptosis during the late phase of acetaminophen hepatotoxicity. Arch Toxicol. 2018 Oct 15.