[CAS NO. 133550-37-5] (+)-Tyrphostin B44
PRODUCTS SPECIFICATIONS [133550-37-5]
DESCRIPTION [133550-37-5]
Overview
| MDL | MFCD00209855 |
|---|---|
| Molecular Weight | 308.33 |
| Molecular Formula | C18H16N2O3 |
| SMILES | O=C(N[C@H](C1=CC=CC=C1)C)/C(C#N)=C/C2=CC=C(O)C(O)=C2 |
Summary
(+)-Tyrphostin B44 (Tyrphostin AG 835) (Compound B50) is an EGRF inhibitor with antitumor activities [1] .
In Vitro
(+)-Tyrphostin B44 (Tyrphostin AG 835) (Compound B50) (0-100 µM) inhibits cell survival with EC 50 values of 3.12, 12.5 and 12.5 µM against CALO, INBL and HeLa cells, respectively [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 100 mg/mL ( 324.33 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.2433 mL | 16.2164 mL | 32.4328 mL |
| 5 mM | 0.6487 mL | 3.2433 mL | 6.4866 mL |
| 10 mM | 0.3243 mL | 1.6216 mL | 3.2433 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (8.11 mM); Clear solution
