[CAS NO. 1345839-28-2] EIPA hydrochloride

Name: EIPA hydrochloride
Brand: Arctom Scientific
SKU: AS940520

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PRODUCTS SPECIFICATIONS [1345839-28-2]

Distributor

Catalog

AS940520

Brand

Arctom Scientific

CAS

1345839-28-2

DESCRIPTION [1345839-28-2]

Overview

MDL	-
Molecular Weight	336.22
Molecular Formula	C11H19Cl2N7O
SMILES	O=C(C1=NC(Cl)=C(N(CC)C(C)C)N=C1N)NC(N)=N.Cl

For research use only. We do not sell to patients.

32 Publications Citing Use of MCE

Summary

EIPA (L593754) hydrochloride is an orally active TRPP3 channel inhibitor with an IC ₅₀ of 10.5 μM. EIPA hydrochloride also enhances autophagy by inhibiting Na ⁺ /H ⁺ -exchanger 3 ( NHE3 ). EIPA hydrochloride inhibits macropinocytosis as well. EIPA hydrochloride can be used in the research of inflammation and cancers, such as gastric cancer , colon carcinoma, pancreatic carcinoma ^[1] ^[2] ^[3] ^[5] .

IC50 & Target

COX-2

In Vitro

EIPA hydrochloride (100 μM, 30 min) suppresses TRPP3-mediated Ca ²⁺ uptake in X. laevis oocytes ^[1] .
EIPA hydrochloride (10-100 μM) reversibly inhibits the basal Na ⁺ current (IC ₅₀ : 19.5 μM) ^[1] .
EIPA hydrochloride (300 μM, 6h) enhances autophagy through NHE3 (Na ⁺ /H ⁺ -exchanger 3) in IEC-18 cells ^[2] .
EIPA hydrochloride (20 μM, 2 h) blocks macropinocytosis-mediated uptake of CA-PZ massively entry in HT-29 cells and MIA PaCa-2 cells ^[3] .
EIPA hydrochloride (30 μM, 3h) attenuates Zinc/Kainate toxicity by decreasing Zn ²⁺ entry in cerebellar granule neurons ^[4] .
EIPA hydrochloride (5-100 μM, 48h) suppresses proliferation of MKN28 cells through up-regulation of p21 expression ^[5] .
EIPA hydrochloride (3 μM, 6 h) inhibits the LPS-induced increase in the level of COX-2 protein ^[7] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay ^[5]

Cell Line:	MKN28 cells
Concentration:	5, 10, 25, 50, and 100 μM
Incubation Time:	48 h
Result:	Inhibited cell proliferation in a dose- and time-dependent manner.

Western Blot Analysis ^[2]

Cell Line:	IEC-18 cells
Concentration:	300 μM
Incubation Time:	6 h
Result:	Increased total LC3-II protein levels and P62 flux. Increased ATG5, 7, 12 and P62 expression.

In Vivo

EIPA hydrochloride (Intravenous injection, 1 mg/kg) dose-dependently attenuates the I/R (Ischemia/reperfusion)-induced renal dysfunction in ddY strain mice ^[6] .
EIPA hydrochloride (oral administration, 10 mg/kg) inhibits LPS-induced inflammation in air pouch-type LPS-induced inflammation model ^[7] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male ddY strain mice ^[6]
Dosage:	1 mg/kg
Administration:	Intravenous injection
Result:	Attenuated histologic renal damage, and imprved the I/R-induced increases in renal ET-1 contents.

Animal Model:	Air pouch-type LPS-induced inflammation model ^[7]
Dosage:	10 mg/kg
Administration:	Oral administration
Result:	Inhibited the LPS-induced infiltration of leukocytes into the pouch. Inhibited the amount of PGE2 in the pouch fluid.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 130 mg/mL ( 386.65 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9742 mL	14.8712 mL	29.7424 mL
5 mM	0.5948 mL	2.9742 mL	5.9485 mL
10 mM	0.2974 mL	1.4871 mL	2.9742 mL

* Please refer to the solubility information to select the appropriate solvent.