[CAS NO. 2413368-61-1] m-PEG12-Thiol

Name: m-PEG12-Thiol
Brand: Arctom Scientific
SKU: AS031495

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PRODUCTS SPECIFICATIONS [2413368-61-1]

Distributor

Catalog

AS031495

Brand

Arctom Scientific

CAS

2413368-61-1

DESCRIPTION [2413368-61-1]

Overview

MDL	MFCD21363241
Molecular Weight	576.74
Molecular Formula	C25H52O12S
SMILES	SCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC

For research use only. We do not sell to patients.

Summary

m-PEG12-Thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs ^[1] .

IC50 & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Liquid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 173.39 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7339 mL	8.6694 mL	17.3388 mL
5 mM	0.3468 mL	1.7339 mL	3.4678 mL
10 mM	0.1734 mL	0.8669 mL	1.7339 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (4.33 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (4.33 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (4.33 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562