[CAS NO. 1350920-22-7] T.cruzi-IN-1

Name: T.cruzi-IN-1
Brand: Arctom Scientific
SKU: AS127303

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PRODUCTS SPECIFICATIONS [1350920-22-7]

Fulfillment

Catalog

AS127303

Brand

Arctom Scientific

CAS

1350920-22-7

DESCRIPTION [1350920-22-7]

Overview

MDL	-
Molecular Weight	390.44
Molecular Formula	C22H25F3N2O
SMILES	O=C(C1CN(CC2=CC=C(C(F)(F)F)C=C2)CCC1)N(C)CC3=CC=CC=C3

For research use only. We do not sell to patients.

Summary

T.cruzi-IN-1 is a potent Trypanosoma cruzi inhibitor with an IC ₅₀ of 8 nM. T.cruzi-IN-1, a 4-trifluoromethyl substituted analog, has the potential for both the acute and chronic stages of Chagas disease ^[1] .

IC50 & Target

Trypanosoma

61.6 μM (IC ₅₀ )

In Vitro

T.cruzi-IN-1 inhibits Trypanosoma cruzi replication and has an IC ₅₀ of 61.6 μM for toxicity ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Powder

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 128.06 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5612 mL	12.8061 mL	25.6121 mL
5 mM	0.5122 mL	2.5612 mL	5.1224 mL
10 mM	0.2561 mL	1.2806 mL	2.5612 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 0.71 mg/mL (1.82 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 0.71 mg/mL (1.82 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 0.71 mg/mL (1.82 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Germain AR, et al. Identification of small-molecule inhibitors of Trypansoma cruzi replication. Bioorg Med Chem Lett. 2011 Dec 1;21(23):7197-200.