[CAS NO. 1364488-67-4] YH239-EE
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PRODUCTS SPECIFICATIONS [1364488-67-4]
Distributor
Catalog
AS939101
Brand
Arctom Scientific
CAS
1364488-67-4
DESCRIPTION [1364488-67-4]
Overview
| MDL | MFCD28099816 |
|---|---|
| Molecular Weight | 504.41 |
| Molecular Formula | C25H27Cl2N3O4 |
| SMILES | O=C(C(N1)=C(C(N(CC2=CC=C(Cl)C=C2)C=O)C(NC(C)(C)C)=O)C3=C1C=C(Cl)C=C3)OCC |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.9825 mL | 9.9126 mL | 19.8251 mL |
| 5 mM | 0.3965 mL | 1.9825 mL | 3.9650 mL |
| 10 mM | 0.1983 mL | 0.9913 mL | 1.9825 mL |
| 50 mM | 0.0397 mL | 0.1983 mL | 0.3965 mL |
Description
YH239-EE, the ethyl ester of YH239, is a potent antagonist and an inducer.
Targets
| p53-MDM2 interaction [1] |
In vitro
YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction. YH239-EE induces cell cycle arrest and causes potent cell apoptosis via activation of p53 and downstream targets in four AML cells (OCI-AML-3 and MOLM-13 with wt p53, NB4 with p53 mutation, and HL60 with p53 deletion).
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